Parenteral nanosuspensions: a brief review from solubility enhancement to more novel and specific applications

Article ID	Journal	Published Year	Pages	File Type
10158168	Acta Pharmaceutica Sinica B	2018	51 Pages	PDF

Abstract

In last decade nanocrystals have emerged as competent solubility enhancement techniques and nowadays there is a paradigm shift in using nanocrystallization approach from simply being solubility enhancement technique to more novel and specific applications. The present review provides a bird×³s eye view of parenteral nanosuspensions and advancements in technology/drug delivery fields.290

Keywords

NCE FITC CLSM SEDS LD50 CFC TBA ADME GRAS EDI HPH HEC PTX BDP P-gp sFl QbD EHDA In vivo fate ASES EPAS d-α-Tocopheryl polyethylene glycol 1000 succinate MDR HPC HPMC CMC PVA AUC DMSO US FDA electrohydrodynamic atomization United States Food and Drug Administration Tem generally recognized as safe Beclomethasone dipropionate Tert-butanol Stabilizer Estimated daily intake Parenteral EPR Critical flocculation concentration Solidification intraperitoneal Intravenous Dimethyl sulfoxide BCs subcutaneous Blood–brain barrier BBB Biopharmaceutical classification system Intramuscular critical micelle concentration fluorescein isothiocyanate SEM Scalability area under curve Scanning electron microscopy Transmission electron microscopy confocal laser scanning microscopy Nanosuspension Enhanced permeability and retention IVIVC High-pressure homogenization Hydroxyethylcellulose Hydroxypropyl cellulose Hydroxypropyl methylcellulose new chemical entities Vitamin E TPGS Paclitaxel polyethylene glycol polyvinyl alcohol PEG Quality by design