Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10158477 | Journal of Pharmacological and Toxicological Methods | 2018 | 46 Pages |
Abstract
With exceptions, hiPSC-CMs are sensitive and exhibit at least 10% delayed or shortened repolarization from pre-addition values and arrhythmia after drug application and thus can provide predictive cardiac electrophysiology data. The baseline electrophysiological parameters vary between iPS cells from different sources, therefore positive and negative control recordings are recommended.
Keywords
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Authors
Corina T. Bot, Krisztina Juhasz, Fabian Haeusermann, Liudmila Polonchuk, Martin Traebert, Sonja Stoelzle-Feix,