Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10159264 | Acta Biomaterialia | 2014 | 7 Pages |
Abstract
The effectiveness of rheological blends of high molecular weight hyaluronic acid (HA) and low molecular weight hydroxypropyl methylcellulose (HPMC) in the prevention of peritoneal adhesions post-surgery is demonstrated. The physical mixture of the two carbohydrates increased the dwell time in the peritoneum while significantly improving the injectability of the polymer compared with HA alone. HA-HPMC treatment decreased the total adhesion area by â¼70% relative to a saline control or no treatment in a repeated cecal injury model in the rabbit. No significant cytotoxicity and minimal inflammation were associated with the blend. Furthermore, no chemical or physical processing was required prior to their use beyond simple mixing.
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Authors
Todd Hoare, Yoon Yeo, Evangelia Bellas, Joost P. Bruggeman, Daniel S. Kohane,