Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10159749 | Acta Biomaterialia | 2012 | 7 Pages |
Abstract
In contact or when engulfed by monocytes wear debris () induce a production of several mediators including pro-inflammatory (TNF-α, IL-1β, IL-6 and IL-18), chemotactic (IL-8) and anti-inflammatory (IL-10) ones. All these factors act in balance with each other and with proteases (MMP-9 ) and their inhibitors (TIMP-1 ) to ensure tissue homeostasis and renewal (ie. osteoclastogenesis). The use of strontium-substituted BCP () can decrease the production of inflammatory cytokines (TNF-α and IL-6), chemokine (IL-8) and proteases inhibitor (TIMP-1). This allows a fine tuning of inflammatory response which cannot be exacerbated due to maintained IL-10 concentration. Moreover, BCP5% favors matrix turnover by decreased TIMP-1 and increased MMP-9 production.
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Authors
E. Buache, F. Velard, E. Bauden, C. Guillaume, E. Jallot, J.M. Nedelec, D. Laurent-Maquin, P. Laquerriere,