Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10159864 | Acta Biomaterialia | 2013 | 7 Pages |
Abstract
Fully aliphatic segmented poly(ether ester amide) copolymers with uniform hard segments prepared by melt polycondensation of α,Ï-hydroxyl end-functionalized polytetrahydrofuran and short glycine or β-alanine bisester-bisoxalamide units hold promise for biomedical applications. For polymers with the hard block contents varying from 10% to 27%, differential scanning calorimetry and atomic force microscopy reveal a highly phase-separated morphology, with ribbon-like nanocrystals dispersed in the soft segment matrix. To relate the polymer properties to the structure of the hard segment, the monomers were prepared and studied by optical and X-ray diffraction measurements. It was shown that the glycine and β-alanine carbonyl ester groups are tilted away from the oxalamide plane, which can affect the degradation rate via hydrolysis of the ester bond.
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Authors
Ya.I. Odarchenko, N.J. Sijbrandi, M. Rosenthal, A.J. Kimenai, E.P.C. Mes, R. Broos, G. Bar, P.J. Dijkstra, J. Feijen, D.A. Ivanov,