Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10160403 | Acta Biomaterialia | 2010 | 9 Pages |
Abstract
The cohesion of calcium phosphate cements can be improved by the addition of substances to either the solid or liquid phase during the setting reaction. This study reports the effect of silica gel on brushite cement cohesion. The cement was prepared using a mixture of β-tricalcium phosphate (β-TCP) and monocalcium phosphate monohydrate as the solid phase, while the liquid phase comprised carboxylic acids silica gel. This cement presents a shorter final setting time (FST), better cohesion and higher amount of unreacted β-TCP than the cement prepared without silica gel. Furthermore, in vivo experiments using rabbits as an animal model showed that after 8 weeks of implantation cements modified with silica gel showed a similar new bone formation volume and more remaining graft in comparison with unmodified cements. Thus, the silica gel could be efficiently applied to reduce cement disintegration and to decrease the resorption rate of brushite cements.
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Authors
Mohammad Hamdan Alkhraisat, Carmen Rueda, Luis Blanco Jerez, Faleh Tamimi Mariño, Jesus Torres, Uwe Gbureck, Enrique Lopez Cabarcos,