Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10162053 | Journal of Pharmaceutical Sciences | 2015 | 12 Pages |
Abstract
Monoclonal antibodies have demonstrated enormous potential as new classes of drugs that confer great benefits to patients, and more than 40 therapeutic antibodies have already been approved for clinical use. In particular, the past 5Â years might be recognized as the period guiding the new era for “engineered antibodies,” with the successful approval of numerous antibody-drug conjugates, bispecific antibodies, and glyco-engineered antibodies for clinical applications. In this review, we summarize the development of antibody engineering technologies that are proving their concepts in the clinic, mainly focusing on the latest trends in defucosylated antibody technologies.
Keywords
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Authors
Rinpei Niwa, Mitsuo Satoh,