Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10162090 | Journal of Pharmaceutical Sciences | 2015 | 9 Pages |
Abstract
The procedure described in this study provides a platform technology for rapidly dissolving, single-dosed cryopellets. The different steps during cryopellet production were investigated, covering droplet generation, droplet freezing in liquid nitrogen (LN2) as well as cryopellet properties. With the setup developed, uniform droplets between 4 and 14 μL were produced. The freezing behavior was similar to approaches reported in the literature. A weight loss reported for droplets frozen in LN2 could not be confirmed. Mechanical stability as observed with texture analysis as well as dissolution time increased with increasing solid content. All cryopellets immediately disintegrated when in contact with the dissolution medium. The dissolution times of amorphous sucrose and trehalose-based cryopellets at different solid content levels were comparable. Crystalline mannitol cryopellets showed in general a higher dissolution time. The formation of δ-mannitol potentially makes the cryopellets suitable as an intermediate product for tableting.
Keywords
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Authors
Matthias Erber, Geoffrey Lee,