Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10162202 | Journal of Pharmaceutical Sciences | 2015 | 23 Pages |
Abstract
Scale up of pan coating process is of high importance to the pharmaceutical and food industry. The number of process variables and their interdependence in a pan coating process can make it a rather complex scale-up problem. This review discusses breaking down the coating process variables into three main categories: pan-related, spray-related, and thermodynamic-related factors. A review on how to scale up each of these factors is presented via two distinct strategies-“macroscopic” and “microscopic” scale-up. In a Quality by Design paradigm, where an increased process understanding is required, there is increased emphasis on “microscopic” scale-up, which by definition ensures a more reproducible process and thereby robust scale-up. This article also reviews the various existing and new modeling and process analytical technology tools that can provide additional information to facilitate a more fundamental understanding of the coating process. © 2015 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 104:3589-3611, 2015
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Anjali M. Agrawal, Preetanshu Pandey,