Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10162218 | Journal of Pharmaceutical Sciences | 2015 | 6 Pages |
Abstract
The objective of this study was to fabricate and characterize electrospun fibers loaded with budesonide with the aim of controlling its release in the gastrointestinal tract. Budesonide is a nonhalogenated glucocorticosteroid drug, highly effective in the treatment of some inflammatory bowel diseases with local action throughout ileum and colon. At this aim, Eudragit® S 100, a polymer soluble at pHÂ >Â 7, commonly used for enteric release of drugs, has been successfully spun into ultrafine fibers loaded with Budesonide (B) at 9% and 20% (w/w) using the electrospinning process. The physico-chemical characterization by scanning electron microscopy, X-ray diffraction, FTIR spectroscopy, and thermal analyses indicated the amorphous nature of budesonide in the electrospun systems. Dissolution rate measurements using a pH-change method showed negligible drug dissolved at pHÂ 1.0 and sustained release at pHÂ 7.2. Therefore, the pharmaceutical systems proposed, made of fibers, represent an effective method for drug targeting to terminal ileum and colon with the aim of improving the local efficacy of this drug.
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Authors
Giovanna Bruni, Lauretta Maggi, Loredana Tammaro, Andrea Canobbio, Rosadele Di Lorenzo, Sharon D'aniello, Chiara Domenighini, Vittorio Berbenni, Chiara Milanese, Amedeo Marini,