Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10162294 | Journal of Pharmaceutical Sciences | 2014 | 8 Pages |
Abstract
Mucoadhesive films containing curcuminâloaded nanoparticles were developed, aiming to prolong the residence time of the dosage form in the oral cavity and to increase drug absorption through the buccal mucosa. Films were prepared by the casting method after incorporation of curcuminâloaded chitosanâcoated polycaprolactone nanoparticles into plasticized chitosan solutions. Different molar masses of mucoadhesive polysaccharide chitosan and concentrations of plasticizer glycerol were used to optimize the preparation conditions. Films obtained using medium and high molar mass chitosan were found to be homogeneous and flexible. Curcuminâloaded nanoparticles were uniformly distributed on the film surface, as evidenced by atomic force microscopy and highâresolution fieldâemission gun scanning electron microscopy (FEGâSEM) images. Analyses of film cross sections using FEGâSEM demonstrate the presence of nanoparticles inside the films. In addition, films proved to have a good rate of hydration in simulated saliva solution, displaying a maximum swelling of around 80% and in vitro prolongedâcontrolled delivery of curcumin. These results indicate that the mucoadhesive films containing nanoparticles offer a promising approach for buccal delivery of curcumin, which may be particularly useful in the treatment of periodontal diseases that require a sustained drug delivery.
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
LetÃcia Mazzarino, Redouane Borsali, Elenara LemosâSenna,