Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10162332 | Journal of Pharmaceutical Sciences | 2014 | 7 Pages |
Abstract
Photoprotective potential and biological consequences (mutagenic potential) of octyl-dimethyl-PABA (ODP), titanium dioxide (TiO2), and montmorillonite (MMT) upon ultraviolet B (UVB) irradiation, alone and in different associations [physical mixtures (PMs)], were evaluated using a Saccharomyces cerevisiae ogg1 mutant (deficient) strain. In addition, we developed and characterized a delaminated TiO2-pillared MMT, called the TiO2-MMT nanocomposite (NC), which was also investigated in terms of its photoprotective and mutagenic potential. Overall, our results revealed an interesting TiO2-MMT NC endowed with antimutagenic activity that can be associated to organic sunscreen molecule (ODP) and still maintain its positive effect, whereas its respective PM is unable to grant antimutagenic protection against UVB. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:2539-2545, 2014
Keywords
Related Topics
Health Sciences
Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Juliana P. Paiva, Bianca A.M.C. Santos, Daniel M. Kibwila, Tula C.W. Gonçalves, A. Viviana Pinto, Carlos R. Rodrigues, Alvaro C. Leitão, Lúcio M. Cabral, Marcelo De Pádula,