| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10162457 | Journal of Pharmaceutical Sciences | 2014 | 9 Pages |
Abstract
We report here for the first time a series of amorphous sucrose/glucose molecular alloys prepared by cryomilling. Differential scanning calorimetry, X-ray powder diffraction and solution proton nuclear magnetic resonance showed that cryomilling drives a direct transformation from a two-phase mixture of crystalline sucrose and glucose, to a single-phase amorphous sucrose/glucose molecular alloy. The molecular alloys displayed a single Tg which varied linearly with composition. The effect of atmospheric moisture and the possibility of localised melting of the material because of milling-related friction were also discussed.
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Authors
Andrew J. Megarry, Jonathan Booth, Jonathan Burley,