Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10162494 | Journal of Pharmaceutical Sciences | 2014 | 12 Pages |
Abstract
The study aims to investigate the impact of annealing hold time and temperature on the primary drying rate/duration of a 10% (w/v) solution of maltodextrin with an emphasis on how the mechanisms of annealing might be understood from the in-vial measurements of the ice crystal growth and the glass transition. The electrical impedance of the solution within a modified glass vial was recorded between 10 and 106 Hz during freeze-drying cycles with varying annealing hold times (1-5 h) and temperatures. Primary drying times decreased by 7%, 27% and 34% (1.1, 4.3 and 5.5 h) with the inclusion of an annealing step at temperatures of -15 °C, -10 °C and -5 °C, respectively. The glass transition was recorded at approximately -16 °C during the re-heating and re-cooling steps, which is close to the glass transition (Tgâ²) reported for 10% (w/v) maltodextrin and therefore indicates that a maximum freeze concentration (~ 86%, w/w, from the Gordon-Taylor equation) was achieved during first freezing, with no further ice being formed on annealing. This observation, coupled to the decrease in electrical resistance that was observed during the annealing hold time, suggests that the reduction in the drying time was because of improved connectivity of ice crystals because of Ostwald ripening rather than devitrification. © 2014 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:1799-1810, 2014
Keywords
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Authors
Geoff Smith, Muhammad Sohail Arshad, Eugene Polygalov, Irina Ermolina,