Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10162652 | Journal of Pharmaceutical Sciences | 2014 | 6 Pages |
Abstract
Scaleâup issues in the tableting process, such as capping, sticking, or differences in tablet thickness, are often observed at the commercial production scale. A new shaped punch, named the size adjusted for scaleâup (SAS) punch, was created to estimate scaleâup issues seen between laboratory scale and commercial scale tableting processes. The SAS punch's head shape was designed to replicate the total compression time of a laboratory tableting machine to that of a commercial tableting machine. Three different lubricated blends were compressed into tablets using a laboratory tableting machine equipped with SAS punches, and any differences in tablet thickness or capping phenomenon were observed. It was found that the new shaped punch could be used to replicate scaleâup issues observed in the commercial tableting machine. The SAS punch was shown to be a useful tool to estimate scaleâup issues in the tableting process. © 2013 Wiley Periodicals, Inc. and the American Pharmacists Association J Pharm Sci 103:235-240, 2014
Keywords
Related Topics
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Pharmacology, Toxicology and Pharmaceutical Science
Drug Discovery
Authors
Shigeru Aoki, Jumpei Uchiyama, Manabu Ito,