| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10165154 | JACC: Heart Failure | 2015 | 9 Pages |
Abstract
In experimental hyperaldosteronism, the increase in Gal-3 expression was associated with cardiac and renal fibrosis and dysfunction but was prevented by pharmacological inhibition (modified citrus pectin) or genetic disruption of Gal-3. These data suggest a key role for Gal-3 in cardiorenal remodeling and dysfunction induced by aldosterone. Gal-3 could be used as a new biotarget for specific pharmacological interventions.
Keywords
Related Topics
Health Sciences
Medicine and Dentistry
Cardiology and Cardiovascular Medicine
Authors
Laurent PhD, Ernesto PhD, Maria PhD, Victoria PhD, Elodie Rousseau, J. Rafael MD, Faiez PhD, MD, Patrick PhD, MD, Natalia PhD,