| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10172025 | Respiratory Investigation | 2014 | 9 Pages |
Abstract
A polymorphism of the BIM gene unique to East Asian people has been detected and is now attracting attention as a factor causing resistance to EGFR-TKI due to decreased BIM activity.
Keywords
Bcl-2-like protein 11HGFEGFR-TKIBH3BcrpAPAf-1Bcl-2 homology domain 3protein kinase CεSRCBCL2L11HDACHSP90TGF-βIL-6PKC-εPI3KPBMCMSTNFκβORRmRNAABC transporterMAPKPFsmessenger RNAadenosine triphosphate-binding cassette transporterinterleukin-6Progression free survivaloverall survivaltransforming growth factor-βEMTEGFR mutationApoptosismedian survival timePeripheral blood mononuclear cellHepatocyte growth factorApoptotic Peptidase Activating Factor 1nuclear factor kappa Bphosphatase and tensin homolog deleted from chromosome 10phosphoinositide 3-kinasefluorescence in situ hybridizationnot applicableFishBIMAcquired resistanceEpidermal growth factor receptor tyrosine kinase inhibitornot significantoverall response rateHeat shock protein 90breast cancer resistance proteinmitogen-activated protein kinasePtenepithelial-to-mesenchymal transition
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Authors
Shinji Takeuchi, Seiji Yano,