| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10172144 | Respiratory Investigation | 2013 | 8 Pages |
Abstract
The results of this study indicated that irbesartan attenuated the development of bleomycin-induced pulmonary fibrosis in mice by decreasing TGF-β1 and MCP-1 via blocking of ATI, by binding to CCR2b, and by PPARγ-mediated inhibition of inflammation.
Keywords
AT1Jun N-terminal kinaseMIP-1αPGF2αCCR2BTGFGW9662ICRPPREsMCP-1CTGFIPFJnkARBsPPARsangiotensin type 1 receptorBALFtransforming growth factorTransforming growth factor βEnzyme-linked immunosorbent assayELISAtumor necrosis factor-αConnective tissue growth factorTNF-αPulmonary fibrosisidiopathic pulmonary fibrosisBronchoalveolar lavage fluidAngiotensin receptor blockersAngiotensin receptor blockermonocyte chemotactic protein 1monocyte chemoattractant protein 1Macrophage inflammatory protein-1αProstaglandin F2αImprinting Control Regionperoxisome proliferator-activated receptorperoxisome proliferator activated receptors
Related Topics
Life Sciences
Immunology and Microbiology
Immunology and Microbiology (General)
Authors
Junichi Tanaka, Shunji Tajima, Katsuaki Asakawa, Takuro Sakagami, Hiroshi Moriyama, Toshinori Takada, Eiichi Suzuki, Ichiei Narita,