Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10225574 | Schizophrenia Research | 2018 | 5 Pages |
Abstract
In schizophrenia, plasma cytokines abnormalities offer vital support for immunopathogenetic basis. However, most of the previous studies on plasma cytokines are confounded by examination of antipsychotic-treated schizophrenia patients. In this study, we examined a large sample of antipsychotic-naïve/free schizophrenia patients (Nâ¯=â¯75) in comparison with healthy controls (Nâ¯=â¯102). Plasma cytokines (Interleukins ([IL] 2, 4, 6, 10, 17), Tumor necrosis factor [TNF] and Interferon gamma [IFN-g]) were assessed using cytometric bead array assay. Schizophrenia patients showed significantly greater levels of IL-6 and lower levels of IL-17 as well as IFN-g in comparison to healthy controls. However, after taking censoring into account and adjusting for potential confounders (sex, age, BMI and smoking), only IL-6 was found to be elevated in patients. Cytokine profile showed differential and pathogenetically relevant correlation with clinical symptoms. Together, these observations offer further support to immunological component in schizophrenia pathogenesis.
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Behavioral Neuroscience
Authors
Sunil Vasu Kalmady, Venkataram Shivakumar, Dania Jose, Vasanthapuram Ravi, Matcheri S. Keshavan, Bangalore N. Gangadhar, Ganesan Venkatasubramanian,