| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10227899 | Biomaterials | 2014 | 9 Pages |
Abstract
Complexation of all siRNAs with PEI led to a significant increase in adsorption to unmodified ePET. TSP-2 siRNA-PEI released from unmodified-ePET silenced TSP-2 in AoSMC. Regardless of the siRNA-PEI complex evaluated, AoSMC migrated into the ePET. siRNA-PEI complexes delivered to AoSMC from dip-coated ePET can result in gene knockdown. This methodology for siRNA delivery may improve the tissue response to vascular and other prosthetics.
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Authors
Christoph S. Nabzdyk, Maggie C. Chun, Hunter S. Oliver-Allen, Saif G. Pathan, Matthew D. Phaneuf, Jin-Oh You, Leena K. Pradhan-Nabzdyk, Frank W. LoGerfo,