Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10228014 | Biomaterials | 2013 | 10 Pages |
Abstract
A novel strategy to construct a therapeutic system based on functionalized AuNPs which can specifically respond to tumor microenvironment was reported. In the therapeutic system, doxorubicin was conjugated to AuNPs via thiol-Au bond by using a peptide substrate, CPLGLAGG, which can be specifically cleaved by the protease. In vivo study shows that after injection of the functionalized AuNPs to the tumor-bearing mice, the over-expressed protease of MMP-2 in tumor tissue and intracellular GSH can lead to the rapid release of the anti-tumor drug (doxorubicin) from the functionalized AuNPs to inhibit tumor growth and realize fluorescently imaging simultaneously. The functionalized AuNPs with tumor-triggered drug release property can further improve the efficacy and reduce side effects significantly.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Wei-Hai Chen, Xiao-Ding Xu, Hui-Zhen Jia, Qi Lei, Guo-Feng Luo, Si-Xue Cheng, Ren-Xi Zhuo, Xian-Zheng Zhang,