Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10228523 | Biomaterials | 2013 | 11 Pages |
Abstract
The most striking toxic effect was the almost complete suppression of the natural killer (NK) cell activity in the spleen at high doses. Other immune parameters affected were: decreased interferon-γ and interleukin (IL)-10 production by concanavalin-A stimulated spleen cells, increased IL-1β and decreased IL-6, IL-10 and TNF-α production by lipopolysaccharide stimulated spleen cells, increase in serum IgM and IgE, and increase in blood neutrophilic granulocytes. For the spleen weight a critical effect dose of 0.37 mg/kg body weight (b.w.) could be established. The lowest critical effect dose (CED) for a 5% change compared to control animals was observed for thymus weight (CED05 0.01 mg/kg b.w.) and for functional immune parameters, i.e. decrease in NK cell activity (CED05 0.06 mg/kg b.w.) and LPS stimulation of spleen cells (CED05 0.04 mg/kg b.w.). These results show that for nanosilver the most sensitive parameters for potential adverse responses were effects on the immune system.
Keywords
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Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Wim H. De Jong, Leo T.M. Van Der Ven, Annemarie Sleijffers, Margriet V.D.Z. Park, Eugene H.J.M. Jansen, Henk Van Loveren, Rob J. Vandebriel,