Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10228844 | Biomaterials | 2013 | 8 Pages |
Abstract
Rapid and effective wound healing requires a coordinated cellular response involving fibroblasts, keratinocytes and vascular endothelial cells (VECs). Impaired wound healing can result in multiple adverse health outcomes and, although antibiotics can forestall infection, treatments that accelerate wound healing are lacking. We now report that topical application of water soluble cerium oxide nanoparticles (Nanoceria) accelerates the healing of full-thickness dermal wounds in mice by a mechanism that involves enhancement of the proliferation and migration of fibroblasts, keratinocytes and VECs. The Nanoceria penetrated into the wound tissue and reduced oxidative damage to cellular membranes and proteins, suggesting a therapeutic potential for topical treatment of wounds with antioxidant nanoparticles.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Srinivasulu Chigurupati, Mohamed R. Mughal, Eitan Okun, Soumen Das, Amit Kumar, Michael McCaffery, Sudipta Seal, Mark P. Mattson,