Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10229013 | Biomaterials | 2013 | 8 Pages |
Abstract
Theranostic agents are attracting a great deal of attention in personalized medicine. Here, we developed a protein-based, facile method for fabrication of nanosized, reduced graphene oxide (nano-rGO) with high stability and low cytotoxicity. We constructed highly integrated photoacoustic/ultrasonic dual-modality imaging and photothermal therapy platforms, and further demonstrated that the prepared nano-rGO can be used as ready-to-use theranostic agents for both photoacoustic imaging and photothermal therapy without further surface modification. Intravenous administration of nano-rGO in tumor-bearing mice showed rapid and significant photoacoustic signal enhancement in the tumor region, indicating its excellence for passive targeting and photoacoustic imaging. Meanwhile, using a continuous-wave near-infrared laser, cancer cells in vivo were efficiently ablated, due to the photothermal effect of nano-rGO. The results suggest that the nano-rGO with protein-assisted fabrication was well suited for photoacoustic imaging and photothermal therapy of tumor, which is promising for theranostic nanomedicine.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Zonghai Sheng, Liang Song, Jiaxiang Zheng, Dehong Hu, Meng He, Mingbin Zheng, Guanhui Gao, Ping Gong, Pengfei Zhang, Yifan Ma, Lintao Cai,