Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10229332 | Biomaterials | 2013 | 8 Pages |
Abstract
We have developed a drug delivery system for prolonged trans-tympanic antibiotic delivery from a single dose administration. Increased permeability to ciprofloxacin of the intact tympanic membrane (TM) was achieved by chemical permeation enhancers (CPEs - bupivacaine, limonene, sodium dodecyl sulfate); this was also seen by CPEs contained within a hydrogel (poloxamer 407) to maintain the formulation at the TM. The CPE-hydrogel formulation had minimal effects on auditory thresholds and tissue response in vivo. CPE-hydrogel formulations have potential for ototopical delivery of ciprofloxacin for the treatment of acute otitis media (AOM) and other middle ear diseases.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Xiaojuan Khoo, Emmanuel J. Simons, Homer H. Chiang, Julia M. Hickey, Vishakha Sabharwal, Stephen I. Pelton, John J. Rosowski, Robert Langer, Daniel S. Kohane,