| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10229721 | Biomaterials | 2011 | 12 Pages |
Abstract
⺠VEGF is covalently immobilized to heparin nanoparticles. ⺠VEGF is clustered at high and low densities, and then placed in fibrin gels. ⺠VEGF conjugated to the particles maintains activity and promotes migration signaling. ⺠In tube formation assay, high density VEGF significantly improves HUVEC branching. ⺠In CAM assay, high density VEGF recruits functional host vessels into fibrin gel.
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Authors
Sean M. Anderson, Shayne N. Siegman, Tatiana Segura,