Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10231385 | Biotechnology Advances | 2015 | 77 Pages |
Abstract
Heart valve tissue engineering could be a possible solution for the limitations of mechanical and biological prostheses, which are commonly used for heart valve replacement. In tissue engineering, cells are seeded into a 3-dimensional platform, termed the scaffold, to make the engineered tissue construct. However, mimicking the mechanical and spatial heterogeneity of a heart valve structure in a fabricated scaffold with uniform cell distribution is daunting when approached conventionally. Bioprinting is an emerging technique that can produce biological products containing matrix and cells, together or separately with morphological, structural and mechanical diversity. This advance increases the possibility of fabricating the structure of a heart valve in vitro and using it as a functional tissue construct for implantation. This review describes the use of bioprinting technology in heart valve tissue engineering.
Keywords
RGDPGSFGF-2STLGAGBATVICPEG-DAVECCNTFTAVRBMP-2ECMComputer-assisted manufacturingα-SMAValvular interstitial cellThree-dimensionalPGANSCarginine–glycine–aspartic acidpolyglycolic acidMRILaser-Induced Forward Transferα-smooth muscle actinLIFTMagnetic resonance imagingTranscatheter aortic valve replacementcomputed tomographyHeart valvetwo-dimensionalCAMCADComputer-assisted designfibroblast growth factor 2ciliary neurotrophic factorStereo lithographyExtracellular matrixBioprintingHydrogelbone morphogenetic protein 2polyethylene glycolPolyethylene glycol diacrylatePoly(ethylene glycol) dimethacrylatePoly-4-hydroxybutyratePEG3-dimensional printingGlycosaminoglycans
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Soumen Jana, Amir Lerman,