Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10231462 | Biotechnology Advances | 2015 | 18 Pages |
Abstract
In addition to apoptosis resistance and cell proliferation capacities, the undifferentiated state also characterizes most cancer cells, especially leukemia cells. Cell differentiation is a multifaceted process that depends on complex regulatory networks that involve transcriptional, post-transcriptional and epigenetic regulation of gene expression. The time- and spatially-dependent expression of lineage-specific genes and genes that control cell growth and cell death is implicated in the process of maturation. The induction of cancer cell differentiation is considered an alternative approach to elicit cell death and proliferation arrest. Differentiation therapy has mainly been developed to treat acute myeloid leukemia, notably with all-trans retinoic acid (ATRA). Numerous molecules from diverse natural or synthetic origins are effective alone or in association with ATRA in both in vitro and in vivo experiments. During the last two decades, pharmaceuticals and natural compounds with various chemical structures, including alkaloids, flavonoids and polyphenols, were identified as potential differentiating agents of hematopoietic pathways and osteogenesis.
Keywords
PI3KCDKHSC5-FUTNFαlncRNAGTPBCREToAPLtPARANKLTGFβFGFHDACMIRNBTETs12-O-tetradecanoylphorbol-13-acetateCMLHspABLhMSCPKCCBPAbelsonRBPGPAVDRCLLPPIasePBGDRXRVPAVD3EpoRIRF-1NF-E2CFU-EFLT3Peptidyl-prolyl cis-trans isomerasenitro-blue tetrazolium chlorideCEBPαPRMT1RunxNuRDLMO2Retinoid-X-receptorFDALdb1TAL-1AMLE26 transformation-specificnuclear factor-erythroid 2PLSCR1Janus kinase1,25-dihydroxyvitamin D3CCAAT/enhancer binding protein αMAPKlong non-coding RNASTATgamma amino butyric acidinterferonIFNinterleukinNucleosome Remodeling and Deacetylaseblast crisisGene expressionTransforming Growth Factor BetaNatural compoundsDifferentiation therapyDrug developmenttumor necrosis factor αHedgehogWorld Health OrganizationFood and Drug AdministrationCancerhematopoietic stem cellshuman mesenchymal stem cellinterferon regulatory factorrunt-related transcription factorfibroblast growth factorPhospholipid scramblase 1phosphoinositide 3 kinase5-fluorouracilleukemiaacute myeloid leukemiaacute lymphocytic leukemiaChronic lymphocytic leukemiaChronic myeloid leukemiaAcute promyelocytic leukemiaFMS-like tyrosine kinase 3Signal transducer and activator of transcriptionBMPbreakpoint cluster regionMultiple myelomaMicroRNAALLhistone deacetylaseValproic acidCREB-binding proteinRNA-binding proteinBone morphogenetic proteinProtein kinase Cmitogen-activated protein kinaseheat-shock proteinporphobilinogen deaminaseJAKWHOcyclin dependent kinaseGABAGlycophorin AGlycoproteinGuanosine triphosphateErythropoietin Receptorvitamin D3 receptorreceptor activator of NF-κB ligand
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Authors
Franck Morceau, Sébastien Chateauvieux, Marion Orsini, Anne Trécul, Mario Dicato, Marc Diederich,