Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10231501 | Biotechnology Advances | 2014 | 9 Pages |
Abstract
Nature has developed an outstanding bio- and molecular diversity as a result of billion years of evolution resulting in a tremendous number of secondary metabolites. Among them a small part has been so far explored for discovery of lead compounds. The lead discovery from natural sources is a technological challenge for the pharmaceutical industry. The bio- and molecular diversity in plants, animals and microorganisms, as sources for new leads, and the remarkable recent developments in NMR, mass spectrometry coupled with advanced separation techniques (LC and GC), high throughput screening, and structure-based virtual screening are discussed in this article.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Strahil Berkov, Blaga Mutafova, Philippe Christen,