Metabolite induction via microorganism co-culture: A potential way to enhance chemical diversity for drug discovery

Article ID	Journal	Published Year	Pages	File Type
10231508	Biotechnology Advances	2014	25 Pages	PDF

Abstract

This review focuses on co-culture studies that aim to increase the diversity of metabolites obtained from microbes. The various strategies are summarized with a special emphasis on the multiple methods of performing co-culture experiments. The analytical approaches for studying these interaction phenomena are discussed, and the chemical diversity and biological activity observed among the induced metabolites are described.

Keywords

MSN IMS SUMO SPME TLC HDAC Deoxynivalenol UHPLC Molecular formula RFLP TRFLP PKS qRT-PCR TIC Dnmt SAHA OPLS NRPS NDF OSMAC 1H-NMR Imaging MS DESI FDA PLS Three-dimensional APCI HTS ZON LDPI nuclear magnetic resonance DNA methyltransferase m/z MS/MS PCA US Food and Drug Administration Suberoylanilide hydroxamic acid Ultraviolet small ubiquitin-related modifier Solid phase microextraction Discriminant analysis Principal component analysis analysis of variance ANOVA Mixed fermentation flame ionization detection NMR partial least square FID Pain DON Zearalenone Polyketide synthase Antimicrobials Refractive index Multistage mass spectrometry Mass spectrometry Tandem mass spectrometry proton nuclear magnetic resonance spectroscopy high-throughput screening Natural products Natural product terminal restriction fragment length polymorphism MALDI Metabolomics quorum sensing microorganisms Microbiome Mass-to-charge ratio Co-culture histone deacetylase polymerase chain reaction quantitative real-time polymerase chain reaction PCR restriction fragment length polymorphism thin layer chromatography high performance liquid chromatography Ultra High Performance Liquid Chromatography HPLC Gas chromatography total ion chromatograms High-resolution desorption electrospray ionization atmospheric pressure chemical ionization matrix-assisted laser desorption ionization Negative ionization