Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10231512 | Biotechnology Advances | 2015 | 18 Pages |
Abstract
Biocatalysis currently is focusing on enzymatic and multi-enzymatic cascade processes instead of single steps imbedded into chemical pathways. Alongside this scientific revolution, this review provides an overview on multi-enzymatic cascades that are responsible for the biosynthesis of some terpenes, alkaloids and polyethers, which are important classes of natural products. Herein, we illustrate the development of studies inspired by multi- and chemo-enzymatic approaches to build the core moieties of polyethers, polypeptide alkaloids, piperidines and pyrrolidines promoted by the joint action of oxidoreductases, hydrolases, cyclases, transaminases and imine reductases.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Renata Sigrist, Bruna Zucoloto da Costa, Anita Jocelyne Marsaioli, Luciana Gonzaga de Oliveira,