Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10231518 | Biotechnology Advances | 2015 | 21 Pages |
Abstract
Water addition to carbon-carbon double bonds using hydratases is attracting great interest in biochemistry. Most of the known hydratases are involved in primary metabolism and to a lesser extent in secondary metabolism. New hydratases have recently been added to the toolbox, both from natural sources or artificial metalloenzymes. In order to comprehensively understand how the hydratases are able to catalyse the water addition to carbon-carbon double bonds, this review will highlight the mechanistic and stereochemical studies of the enzymatic water addition to carbon-carbon double bonds, focusing on the syn/anti-addition and stereochemistry of the reaction.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Bi-Shuang Chen, Linda G. Otten, Ulf Hanefeld,