Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10231553 | Biotechnology Advances | 2013 | 24 Pages |
Abstract
In order to decrease carbon emissions and negative environmental impacts of various pollutants, more bulk and/or fine chemicals are produced by bioprocesses, replacing the traditional energy and fossil based intensive route. The Gram-negative rod-shaped bacterium, Escherichia coli has been studied extensively on a fundamental and applied level and has become a predominant host microorganism for industrial applications. Furthermore, metabolic engineering of E. coli for the enhanced biochemical production has been significantly promoted by the integrated use of recent developments in systems biology, synthetic biology and evolutionary engineering. In this review, we focus on recent efforts devoted to the use of genetically engineered E. coli as a sustainable platform for the production of industrially important biochemicals such as biofuels, organic acids, amino acids, sugar alcohols and biopolymers. In addition, representative secondary metabolites produced by E. coli will be systematically discussed and the successful strategies for strain improvements will be highlighted. Moreover, this review presents guidelines for future developments in the bio-based chemical production using E. coli as an industrial platform.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Xianzhong Chen, Li Zhou, Kangming Tian, Ashwani Kumar, Suren Singh, Bernard A. Prior, Zhengxiang Wang,