Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10231899 | Computational Biology and Chemistry | 2011 | 15 Pages |
Abstract
⺠Structure alignment methods are used to assign proteins to fold groups. ⺠The accuracy of this procedure is difficult to test as the definition of folds can be debated. ⺠By defining folds topologically and building decoys with defined fold the accuracy of fold assignments can be tested. ⺠Protein structure alignments decoys of different fold can be assigned a high significance, leading to errors in fold classification. ⺠This observation can be extended to comparisons between decoy models and real protein structures.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Siv Midtun Hollup, Michael I. Sadowski, Inge Jonassen, William R. Taylor,