Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10231986 | Computational Biology and Chemistry | 2005 | 12 Pages |
Abstract
Overlapping genes in mammalian genomes are unexpected phenomena even though hundreds of pairs of protein coding overlapping genes have been reported so far. Overlapping genes can be divided into different categories based on direction of transcription as well as on sequence segments being shared between overlapping coding regions. The biologic functions of natural antisense transcripts, their involvement in physiological processes and gene regulation in living organisms are not fully understood. Number of documented examples indicates that they may exert control at various levels of gene expression, such as transcription, mRNA processing, splicing, stability, transport, and translation. Similarly, evolutionary origin of such genes is not known, existing hypotheses can explain only selected cases of mammalian gene overlaps which could originate as result of rearrangements, overprinting and/or adoption of signals in the neighboring gene locus.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Izabela Makalowska, Chiao-Feng Lin, Wojciech Makalowski,