| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10232108 | Current Opinion in Biotechnology | 2013 | 7 Pages |
Abstract
- Role of transcription in regulating metabolic fluxes is currently highly debated.
- Flux distributions are resilient against perturbations of transcriptional networks.
- Findings suggest that many enzymes in central metabolism are overabundant.
- Overabundance may protect from fluctuations and allow more rapid responses.
- New 'omics' studies further highlight the suboptimal regulation of gene expression.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Karl Kochanowski, Uwe Sauer, Victor Chubukov,