| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10232263 | Current Opinion in Biotechnology | 2011 | 9 Pages |
Abstract
⺠Glycosyltransferases (GTs) are an important class of enzyme as both drug targets and synthetic catalysts. ⺠Two predominant GT folds (GT-A and GT-B) enable the connection between a vast range of sugar donors and acceptors representing a wide array of regiospecificities and stereospecificities. ⺠Although few 'general' rules exist, rational engineering has led to GTs with altered specificities (sugar donor and/or acceptors). ⺠In the context of engineered GTs, an enhancement of promiscuity often correlates with an increase in overall proficiency.
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Authors
Aram Chang, Shanteri Singh, George N Jr., Jon S Thorson,