| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10232270 | Current Opinion in Biotechnology | 2011 | 9 Pages |
Abstract
⺠Designed repeat protein scaffolds form a promising alternative to antibodies. ⺠These proteins lack disulfides, allowing soluble expression in the cytoplasm of E. coli. ⺠Novel molecular formats can be engineered in a convenient manner. ⺠DARPins, TPRs, αREPs and armadillos are examples of consensus designed scaffolds. ⺠Novel applications of these proteins, particularly DARPins, are highlighted.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Ykelien L Boersma, Andreas Plückthun,