| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10232272 | Current Opinion in Biotechnology | 2011 | 9 Pages |
Abstract
⺠New biodegradable polymers, for example, flexible polypeptide chains, are being developed as a substitute for PEGylation. ⺠Fusion to the IgG Fc region is an established method to prolong half-life of small-sized protein therapeutics. ⺠The half-life of antibodies has been extended by increasing the pH-dependent interaction with the neonatal Fc receptor. ⺠Fusion to albumin is increasingly used for half-life extension also implementing recycling by the neonatal Fc receptor. ⺠Fusion to albumin-binding moieties has emerged as half-life extension strategy utilizing noncovalent interaction with albumin.
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Authors
Roland E Kontermann,