| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10232273 | Current Opinion in Biotechnology | 2011 | 5 Pages |
Abstract
⺠In this manuscript we review the application of nanobodies for molecular imaging. ⺠Nanobodies show rapid molecular targeting with fast clearance of unbound probe in vivo.⺠The pharmacokinetic profile of nanobodies is compatible with the use of short-lived radioisotopes for imaging with positron emission tomography. ⺠Nanobodies generate specific contrast at target sites within the first hour after intravenous injection. ⺠Nanobodies behave as magic bullets for molecular imaging of cell membrane antigens in vivo.
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Authors
Ilse Vaneycken, Matthias D'huyvetter, Sophie Hernot, Jens De Vos, Catarina Xavier, Nick Devoogdt, Vicky Caveliers, Tony Lahoutte,