| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10232391 | Current Opinion in Biotechnology | 2005 | 9 Pages |
Abstract
Basic fibroblast growth factor and members of the transforming growth factor-β superfamily are important regulators of human embryonic stem cell (hESC) self-renewal. Extensive cross-talk between the intracellular signaling pathways activated by these factors contributes to maintenance of the undifferentiated hESC state. Understanding the molecular regulation of hESC self-renewal will facilitate the design of improved systems for hESC propagation and provide a foundation for strategies to direct the differentiation of hESCs to clinically relevant cell types.
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Authors
BM Rao, PW Zandstra,