Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10232438 | Current Opinion in Biotechnology | 2005 | 11 Pages |
Abstract
Over the past 30 years, monoclonal antibodies have become the standard binding proteins and currently find applications in research, diagnostics and therapy. Yet, monoclonal antibodies now face strong competition from synthetic antibody libraries in combination with powerful library selection technologies. More recently, an increased understanding of other natural binding proteins together with advances in protein engineering, selection and evolution technologies has also triggered the exploration of numerous other protein architectures for the generation of designed binding molecules. Valuable protein-binding scaffolds have been obtained and represent promising alternatives to antibodies for biotechnological and, potentially, clinical applications.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
H Kaspar Binz, Andreas Plückthun,