| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10232489 | Current Opinion in Biotechnology | 2005 | 6 Pages |
Abstract
The principal bottleneck for the utilization of small-molecule probes in live cells is the shortage of methodologies for targeting them with very high specificity to biological molecules or compartments of interest. Recently developed methods for labeling proteins with small-molecule probes in cells employ special protein or peptide handles that recruit small-molecule ligands, harness enzymes to catalyze small-molecule conjugation or hijack the cell's protein translation machinery.
Keywords
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Irwin Chen, Alice Y Ting,