Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10232782 | Current Opinion in Biotechnology | 2005 | 11 Pages |
Abstract
G-protein-coupled receptors (GPCRs) are valuable molecular targets for drug discovery. An important aspect of the early drug discovery process is the design and implementation of high-throughput GPCR functional assays that allow the cost-effective screening of large compound libraries to identify novel drug candidates. Several functional assay kits based on fluorescence and/or chemiluminescence detection are commercially available for convenient screen development, each having advantages and disadvantages. In addition, new GPCR biosensors and high-content imaging technologies have recently been developed that hold promise for the development of functional GPCR screens in living cells.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
William Thomsen, John Frazer, David Unett,