Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
10234370 | Food and Bioproducts Processing | 2005 | 6 Pages |
Abstract
The mode of cell uptake, relative cytotoxicity and efficacy of poly (l-lysine iso-phthalamide)-drug conjugates, PEG-graft poly (l-lysine iso-phthalamide)-drug containing micelles, poly (l-lysine iso-phthalamide) modified drug/protein nanospheres and unmodified protein nanospheres as potential delivery systems have been evaluated using doxorubicin and polymethine fluorophores as model drugs. pH dependent cell membrane lysis has been demonstrated using a haemolysis model and the cytotoxicity of the polymeric system evaluated using standard MTT and LDH activity assays. In-vitro toxicity and cellular targeting data are presented and the potential healthcare impact of such systems is discussed.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
M.E. Eccleston, S.L. Williams, Z. Yue, R. Chen, C.K. Lee, E. Anikina, C. Pawlyn, M.A. Barrand, N.K.H. Slater,