| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10234602 | Metabolic Engineering | 2012 | 12 Pages |
Abstract
⺠β-oxidation actively contributes to adipic acid catabolism. ⺠In P. chrysogenum, β-oxidation is localized in the peroxisome and in the mitochondrion. ⺠Acyl CoA OXs are peroxisomal while DHs are peroxisomal and mitochondrial. ⺠Deletion of Pc20g01800 and Pc20g07920 resulted in a 1.6 and 3.7X increase in ad-6APA. ⺠Pc20g07920Πmutant showed an improved (8X) incorporation of adipate into β-lactams.
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Authors
Tânia Veiga, Andreas K. Gombert, Nils Landes, Maarten D. Verhoeven, Jan A.K.W. Kiel, Arjen M. Krikken, Jeroen G. Nijland, Hesselien Touw, Marijke A.H. Luttik, John C. van der Toorn, Arnold J.M. Driessen, Roel A.L. Bovenberg, Marco A. van den Berg,