| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10235025 | New Biotechnology | 2015 | 11 Pages |
Abstract
- Crystal structures of transthyretin (TTR) in complex with curcumin and 16α-bromo estradiol have been determined.
- Curcumin and its degradation product ferulic acid bind in the central cavity.
- The position of bromine in 16α-bromo estradiol offers interesting insights for anti-amyloidogenic inhibitors.
- Solubilizing mixed solutions for hydrophobic ligands allow long duration soaking into crystals and act as cryoprotectants.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Lidia Ciccone, Livia Tepshi, Susanna Nencetti, Enrico A. Stura,