| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10235042 | New Biotechnology | 2015 | 7 Pages |
Abstract
Availability of high quality synthetic mRNAs (syn-mRNAs) has enabled progress in their applications. Important structural features and quality requirements are discussed. Developments in the application of mRNA-mediated manipulation of cells are presented (i) mRNA-directed expression of antigens in dendritic cells for vaccination projects in oncogenesis, infectious disease and allergy prevention; (ii) reprogramming of human fibroblasts to induced pluripotent stem cells with their subsequent differentiation to the desired cell type; (iii) applications in gene therapy.
Related Topics
Physical Sciences and Engineering
Chemical Engineering
Bioengineering
Authors
Elgar Susanne Quabius, Guido Krupp,