An analysis of the factors that affect the dissociation of inclusion bodies and the refolding of endostatin under high pressure

Article ID	Journal	Published Year	Pages	File Type
10235425	Process Biochemistry	2013	10 Pages	PDF

Abstract

âº Factors that affect the refolding of endostatin under high pressure were studied. âº Inclusion bodies (IBS) produced at lower temperature present higher solubility. âº The IBs are dissociated at 2.4Â kbar, but refolding occurs at 0.4Â kbar. âº Sub-zero temperature in association to high pressure increase IBs dissociation.

Keywords

Endostatin Refolding High hydrostatic pressure Inclusion bodies Aggregates

Related Topics

Physical Sciences and Engineering Chemical Engineering Bioengineering

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An analysis of the factors that affect the dissociation of inclusion bodies and the refolding of endostatin under high pressure

Authors

R.M. Chura-Chambi, Y. Cordeiro, N.V. Malavasi, L.S. Lemke, D. Rodrigues, L. Morganti,