| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 10235504 | Process Biochemistry | 2012 | 6 Pages |
Abstract
⺠TMC terminal decarboxylation is carried out by the TmcJ-assisted TmcK in Streptomyces CK4412. ⺠TMC terminal decarboxylation is one of the rate-limiting steps in TMC biosynthesis. ⺠C5-deoxy-3â³-carboxylic TMC in Streptomyces CK4412 failed to show PP1 selectivity over PP2A. ⺠C5-deoxy-3â³-carboxylic TMC in Streptomyces CK4412 exhibited reduced cytotoxicity. ⺠Modification of C3â³ and/or C5 of TMC differentiates multiple biological activities.
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Authors
Ji-Hye Nah, Si-Sun Choi, Dongju Kim, Hwa Sung Shin, David H. Sherman, Eung-Soo Kim,